At her new Catholic school for girls, Honey Kisaragi, a 16-year-old innocent, finds herself captivated by her surroundings and new best friend, Natsuko Aki, along with the faculty. However, her life quickly changes when she hears her scientist father, Dr. Kisaragi, calling for help. Racing to his aid, Honey's clothes transform into various costumes, revealing her extraordinary ability. Despite her newfound powers, tragedy soon strikes as Honey returns home to find her father dying in the arms of reporter, Seiji Hayami. Nevertheless, from her father’s robot, Honey discovers she is a unique android named "Cutie Honey," with the capability to transform into seven different shapes. A wealthy group of female cyborgs, Panther Claw, seeks to obtain Honey’s technology, which allows her to change airborne particles into any element they wish. With her secret identity in jeopardy, Honey honours her late father by facing any challenges Panther Claw set her way.
As the enigmatic creatures of soil from the land of the dead, known as Disas, invaded, humanity was saved from the brink of crisis by a group of magical girls who had acquired a mysterious power. However, three years have passed and the girls have returned to their normal lives, only to have new incidents disrupt their routine. The once-saviors of humanity, known as "The Magical Five," now face daily battles for survival as fate toys with their existence.
In a Japan infested with monsters, an academy was established to train Magical Girls as a countermeasure. A monster named Girlande infiltrates the school as a teacher under the alias Eiji Asagi. Everything seemed to be going smoothly until he caught the eye of a certain Magical Girl. Her name is Hibari Hinagi. It turns out they met ten years ago, and despite being a Magical Girl, she has become a "yandere" who is fanatically obsessed with Girlande (Eiji)! After she offers her cooperation, Eiji decides to take her along on his missions. However, this Magical Girl turns out to be a total klutz...!?